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KMID : 0361020010440060576
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Korean Journal of Otolaryngology - Head and Neck Surgery
2001 Volume.44 No. 6 p.576 ~ p.582
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Relations between the concentrations of IL-1β and TNF-α and clinical features in middle ear effusion
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박철원/Chul Won Park
이승환/최준석/정승원/박혜경/Seung Hwan Lee/Joon Suk Choi/Seung Won Jeong/Hye Kyung Park
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Abstract
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Background and Objectives : Inflammatory mediators retained in middle ear effusion are important in influencing the clinical outcome of this disease. Interleukins and tumor necrosis factor, important immunomodulatory proteins, undoubtedly
influence
middle ear effusion. Materials and Methods : We analyzed 72 human middle ear effusion samples for IL-1β and TNF-α and tried to elucidate the relationship between the levels of IL-1β and TNF-α and clinical findings in OME patients. Results :
1)
IL-1β and TNF-α correlated inversely (P<0.05) with age. The younger the patient, the higher the level of IL-1β and TNF-α in middle ear effusion by simple linear regression analysis.
2) Significantly higher mean levels (P<0.05) of IL-1β were
observed in effusion from patients who showed recurrence.
3) The level of TNF-α was significantly higher in men than in
women.
4) Any differences of IL-1βand TNF-α levels are not found
depending on other clinical variables. i.e. sex, duration of disease,
bilaterality, type of effusion, etc. Conclusion : The results of this
study show that IL-1β and TNF-α are present in human middle
ear effusion of otitis media and suggest that these cytokines may be
important mediators involved in the disease processes of otitis
media.
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